MOTS-C

• Enhances insulin sensitivity and glucose metabolism — relevant to type 2 diabetes research
• Promotes fat oxidation and supports healthy body composition
• Improves exercise endurance and capacity in animal models
• Studied for anti-aging effects and healthspan extension
• Activates AMPK and regulates mitochondrial biogenesis
• May help reverse metabolic dysfunction associated with aging

• Discovery published in Cell Metabolism (2015) by Lee et al.; identified as a mitochondria-encoded regulator of insulin resistance in animal models
• Animal studies show increased exercise capacity, reduced fat mass, and improved glucose tolerance
• MOTS-C levels naturally decline in aged animal models — studied as a candidate longevity biomarker
• 2021 preclinical research demonstrates MOTS-C administration reverses age-related insulin resistance in aged mice
• One of the only peptides encoded in mitochondrial (rather than nuclear) DNA

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