MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a novel mitochondria-derived peptide encoded within mitochondrial DNA. It is one of the most exciting discoveries in longevity and metabolic research, functioning as a metabolic regulator that enhances insulin sensitivity, promotes fat oxidation, and improves exercise capacity.

MOTS-C

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Enhances insulin sensitivity and glucose metabolism — relevant to type 2 diabetes research

Promotes fat oxidation and supports healthy body composition

Improves exercise endurance and capacity in animal models

Studied for anti-aging effects and healthspan extension

Activates AMPK and regulates mitochondrial biogenesis

May help reverse metabolic dysfunction associated with aging
Discovery published in Cell Metabolism (2015) by Lee et al.; identified as a mitochondria-encoded regulator of insulin resistance in animal models

Animal studies show increased exercise capacity, reduced fat mass, and improved glucose tolerance

MOTS-C levels naturally decline in aged animal models — studied as a candidate longevity biomarker

2021 preclinical research demonstrates MOTS-C administration reverses age-related insulin resistance in aged mice

One of the only peptides encoded in mitochondrial (rather than nuclear) DNA
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MOTS-C

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Research Background

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